Tailored to each weighing application, GWP® Verification is a unique, risk-based service that helps eliminate redundant or erroneous testing. METTLER TOLEDO’s GWP® -The Weighing Standard-can help manufacturers implement the new USP regulations. Ensuring Accuracy in the New EnvironmentĪlthough these revisions imply that unnecessary testing must be eliminated to protect manufacturing margins in today’s highly competitive pharmaceutical market, they continue to underscore that weighing accuracy is non-negotiable. This change is expected to provide significant time savings which, if accompanied by weighing accuracy, will offer monetary savings as well. Additionally-and perhaps most importantly to pharmaceutical manufacturers-daily testing recommendations have been dropped. This requirement is clearly applied to the sample weight itself-and not to the tare vessel. Very importantly, it is recommended to only weigh net samples which weigh sufficiently more than the minimum weight to account for fluctuations in the balance’s performance due to varying influences from the environment and the balance operators.
It details that balance performance verification should be carried out using a risk-based approach. General Chapter 1251 provides additional clarification on the new procedures and extends the scope to any balance used for an analytical procedure. Since accuracy can only be gauged using weights that are at least 5% of an instrument’s capacity, test weight selection criteria have also been modified accordingly (weights smaller than 5% cannot assess systematic deviations sufficiently well enough).Īchieve Time Savings without Compromising Accuracy The revised chapter details a relatively demanding balance assessment, outlining accuracy and repeatability tests for calibrated balances used to weigh analytes for quantitative measures. The new requirements of General Chapter 41 are mandatory. METTLER TOLEDO’s Global Weighing Standard: Good Weighing Practice™ (GWP®) can help consumers put the new standards into practice in a structured and effective way.
The revisions to both chapters in the Second Supplement to USP 36-NF 31 aim to help US pharmaceutical manufacturers and suppliers ensure accuracy and eliminate costly over-testing. In addition, they frequently commented that General Chapter 1251 (“Weighing on an Analytical Balance”) no longer represented state-of-the-art weighing practices.
#Usp 41 chapter 41 free#
In addition, METTLER TOLEDO is also offering a wealth of information on their website including a free white paper and a video as well as the opportunity to register for an easy e-learning course.įor a long time balance users and manufacturers argued that balance assessment as per USP’s General Chapter 41 (“Balances”) was unclear and difficult to comply with. With the revised chapters becoming official on 1st December, 2013, METTLER TOLEDO is providing a free on-demand webinar to explain how balance quality management will be affected, focusing on the determination of minimum weight and execution of routine testing. The new revisions define modified balance test procedures for the US pharmaceutical industry and also apply to companies exporting to the US. With just six months to comply, METTLER TOLEDO’s global weighing standard, GWP®, can help pharmaceutical manufacturers and suppliers to meet the new requirements. On the 3rd June, 2013, United States Pharmacopeia (USP) published the revised mandatory Chapter 41 on balances as well as new updates to the advisory Chapter 1251. METTLER TOLEDO’s unique GWP® Verification service helps companies comply with the new revisions
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